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- M B Feany, D C Anthony, M P Frosch, W Zane, and U De Girolami.
- Department of Pathology, Brigham and Women's Hospital and Children's Hospital, Boston, MA, USA.
- Brain Pathol. 2001 Jan 1; 11 (1): 121-2, 125.
AbstractThe August COM: Acute methanol poisoning is an uncommon, but well-recognized, cause of central nervous system injury. We present two autopsy cases showing the classic neuropathologic injuries in acute methanol poisoning: putamen and white matter necrosis and hemorrhage. In Case 1, putamen hemorrhages were striking; white matter pathology predominated in Case 2. The precise mechanism of methanol toxicity is unclear. Direct toxicity of metabolites, particularly formic acid, as well as ischemic injury and acidosis likely play a role. Methanol is readily available in many commercial products, and may be ingested accidentally or intentionally.
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