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Case Reports
Symptomatic Sinus Bradycardia in a Patient with Solitary Fibrous Tumor/Hemangiopericytoma Treated with Pazopanib.
- Wataru Shioyama, Toru Oka, Risa Kamada, Toshinari Yagi, Katsuhiko Nakanishi, Tatsuya Nishikawa, Taku Yasui, and Masashi Fujita.
- Department of Onco-Cardiology, Osaka International Cancer Institute, Japan.
- Intern. Med. 2021 Sep 15; 60 (18): 2973-2977.
AbstractPazopanib, a multi-targeted tyrosine kinase inhibitor, is associated with cardiovascular adverse events, such as hypertension, cardiac dysfunction, and thromboembolism. However, symptomatic pazopanib-related bradycardia is uncommon. We herein report a case of symptomatic bradycardia of 35 beats per minute in a patient with solitary fibrous tumor/hemangiopericytoma (SFT/HPC) treated with pazopanib for 1 month. His heart rate recovered to a normal range soon after pazopanib cessation. He restarted pazopanib at a reduced dose, which was continued without SFT/HPC progression or bradycardia recurrence. This case highlights the possibility of bradycardia induced by pazopanib and the importance of monitoring the patient's heart rate.
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