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- Koki Nakashima, Yoshiki Demura, Masayuki Sato, Yuya Fujii, Kazunari Igarashi, and Tamotsu Ishizuka.
- Department of Respiratory Medicine, Municipal Tsuruga Hospital, Japan.
- Intern. Med. 2021 Sep 15; 60 (18): 3009-3013.
AbstractPseudo-progression is a phenomenon induced by treatment with immune checkpoint inhibitors and is characterized by an increase in tumor size or the appearance of new lesions, followed by tumor regression. However, life-threatening conditions, such as cardiac tamponade, can develop in such patients. We herein report on a 69-year-old man with lung adenocarcinoma who developed cardiac tamponade as a manifestation of pseudo-progression induced by treatment with atezolizumab combined with cytotoxic chemotherapy. After managing the cardiac tamponade, atezolizumab was successfully re-administered along with cytotoxic chemotherapy without disease progression.
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