• Eur. J. Clin. Pharmacol. · Jan 1992

    Randomized Controlled Trial Clinical Trial

    Effects of thiopentone/suxamethonium on intraocular pressure after pretreatment with alfentanil.

    • H Polarz, H Böhrer, F Fleischer, T Huster, H Bauer, and J Wolfrum.
    • Department of Anaesthesia, University of Heidelberg, FRG.
    • Eur. J. Clin. Pharmacol. 1992 Jan 1; 43 (3): 311-3.

    AbstractThe effects of pretreatment with alfentanil on intraocular pressure (IOP) were investigated in 40 patients undergoing ophthalmic surgery. Patients were randomly allocated to two study groups. Group 1 patients (n = 20) received alfentanil 15 micrograms.kg-1, vecuronium 0.01 mg.kg-1, thiopentone 3-4 mg.kg-1, and suxamethonium 1 mg.kg-1 for anaesthetic induction, whereas patients in group 2 (n = 20) received vecuronium 0.01 mg.kg-1, thiopentone 3-4 mg.kg-1, and suxamethonium 1 mg.kg-1. A total of seven measurements of intraocular pressure were taken in each patient, starting before premedication and ending after extubation of the trachea. In group 2 patients, there was an increase in IOP after endotracheal intubation. In group 1 patients, a decrease in IOP occurred which was related to the decrease in arterial blood pressure. We conclude that alfentanil pretreatment can prevent the increase in IOP following suxamethonium administration.

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