• E Burke, E Haber, C W Pike, and R Sonti.
• Medstar Georgetown University Hospital, Division of Pulmonary, Critical Care, and Sleep Medicine, Washington, DC 20007, United States.
• Med Intensiva. 2021 Aug 1; 45 (6): 325331325-331.

ObjectiveTo describe outcomes of critically ill patients with COVID-19, particularly the association of renal replacement therapy to mortality.DesignA single-center prospective observational study was carried out.SettingICU of a tertiary care center.PatientsConsecutive adults with COVID-19 admitted to the ICU.InterventionRenal replacement therapy.Main Variables Of InterestDemographic data, medical history, illness severity, type of oxygen therapy, laboratory data and use of renal replacement therapy to generate a logistic regression model describing independent risk factors for mortality.ResultsOf the total of 166 patients, 51% were mechanically ventilated and 26% required renal replacement therapy. The overall hospital mortality rate was 36%, versus 56% for those requiring renal replacement therapy, and 68% for those with both mechanical ventilation and renal replacement therapy. The logistic regression model identified four independent risk factors for mortality: age (adjusted OR 2.8 [95% CI 1.8-4.4] for every 10-year increase), mechanical ventilation (4.2 [1.7-10.6]), need for continuous venovenous hemofiltration (2.3 [1.3-4.0]) and C-reactive protein (1.1 [1.0-1.2] for every 10 mg/L increase).ConclusionsIn our cohort, acute kidney injury requiring renal replacement therapy was associated to a high mortality rate similar to that associated to the need for mechanical ventilation, while multiorgan failure necessitating both techniques implied an extremely high mortality risk.© 2021 Elsevier España, S.L.U. y SEMICYUC. All rights reserved.

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