• Martin Marziniak, Ngoc Quan Phan, Ulrike Raap, Dorothee Siepmann, Funda Schürmeyer-Horst, Esther Pogatzki-Zahn, Thomas Niederstadt, and Sonja Ständer.
• Department of Neurology, University Hospital Münster, Münster, Germany.
• J. Am. Acad. Dermatol. 2011 Oct 1; 65 (4): 756-762.

BackgroundBrachioradial pruritus (BRP) describes a rare form of itching occurring at the dorsolateral part of the forearms. Recent case reports suggest that BRP may be attributed to cervical lesions or spine neoplasms.ObjectiveWe sought to determine the incidence of cervical spine changes in BRP and to correlate the localization of spinal lesions with the dermatomal presence of pruritus.MethodsMagnetic resonance tomography (MRT) of the cervical spinal cord, a chest x-ray, and a skin biopsy were performed in 41 patients (28 female, 13 male; 59.0 ± 10.6 years) with BRP. Patients completed an itch questionnaire (NeuroDerm Questionnaire) that included a dermatome chart and the Northwick Park Neck Pain Questionnaire.ResultsThe patients marked the locations C5 (90.2%) and C6 (100%) on the dermatome chart. All patients had detectable MRT changes. In 80.5% of the patients, stenosis of the intervertebral foramen or protrusions of the cervical disk led to nerve compression. The location of the nerve compression lesions correlated significantly with the dermatomal localization of the pruritus (Spearman correlation coefficient 0.893; P < .01). No spinal neoplasm was observed, and 19.5% of the patients had degenerative changes without significant correlation to the dermatomal localization of pruritus.LimitationNo healthy control group without pruritus was investigated.ConclusionBRP may result from cervical nerve compression, and rarely, it may also stem from degenerative changes. Our findings suggest that even slight cervical changes detected on MRT may alter itch afferents and lead to BRP. Spinal cord tumors are rare and should be ruled out by a cervical spine MRT.Copyright © 2010 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.

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