• Paisan Ruamviboonsuk, Lai Timothy Y Y TYY Deparment of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China., Andrew Chang, Chi-Chun Lai, William F Mieler, Lam Dennis S C DSC International Eye Research Institute of the Chinese University of Hong Kong (Shenzhen), Shenzhen, China. , and for Asia-Pacific Vitreo-Retina Society.
• Department of Ophthalmology, Rajavithi Hospital, College of Medicine, Rangsit University, Bangkok, Thailand.
• Asia Pac J Ophthalmol (Phila). 2020 Mar 1; 9 (2): 85-87.

AbstractThe proposed doses of chloroquine (CQ) and hydroxychloroquine (HCQ) for treatment of COVID-19 (1000 mg/day for 10 days, CQ; 800 mg first day then 400 mg/day for 5 days, HCQ) in many guidelines worldwide, are considerably higher than the maximum recommended daily safe doses of both agents (≤2.3 mg/kg/day, CQ; ≤5.0 mg/kg/day, HCQ) for development of retinal toxicity. Irreversible retinal damage can occur if the exposure to the safe doses is >5 years. It is not known whether exposure to high doses over a short period of time can also cause the damage. We recommend that before prescribing CQ or HCQ, history of ocular disease should be obtained to avoid the prescription if appropriate. If either agent is to be used, routine baseline ocular examination is not absolutely necessary. Patients who do not have ocular disease should also be informed about the potential risk of retinal toxicity. Both agents, however, have not yet been proven to be beneficial to COVID-19.

22 keywords...

hide…