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Epidemiol Psychiatr Sci · Dec 2019
Esketamine for treatment resistant depression: a trick of smoke and mirrors?
- C Gastaldon, D Papola, G Ostuzzi, and C Barbui.
- Department of Neuroscience, Biomedicine and Movement Sciences, Section of Psychiatry, World Health Organization Collaborating Centre for Research and Training in Mental Health and Service Evaluation, University of Verona, Verona, Italy.
- Epidemiol Psychiatr Sci. 2019 Dec 16; 29: e79.
AbstractIn March 2019, the US Food and Drug Administration (FDA) approved a nasal spray formulation of esketamine for the treatment of resistant depression in adults. Esketamine is the S-enantiomer of ketamine, an FDA-approved anaesthetic, known to cause dissociation and, occasionally, hallucinations. While ketamine has not been approved for depression in the USA or in any other country, it has been used off-label in cases of severe depression. This commentary critically reviewed the evidence on esketamine submitted to the FDA, aiming to draw implications for clinical practice, research and regulatory science.
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