• Christopher Olson, Archana Jhawar, Zane Elfessi, and Richard Doyle.
• Jesse Brown VA Medical Center, 820 South Damen Avenue, Chicago, IL 60612, United States of America. Electronic address: Christopher.Olson1@va.gov.
• Am J Emerg Med. 2021 Oct 1; 48: 375.e5-375.e6.

AbstractPriapism is a severe urologic condition requiring emergency management. Ischemic priapism is the most common subtype which is characterized by a long-lasting, painful, and rigid erection which can be caused by medications with alpha-adrenergic properties such as hydroxyzine. Typically, medication-induced priapism is reported at therapeutic doses and few case reports exist implicating medication overdose as the cause. We report a case of a patient taking hypercompliant doses of hydroxyzine hydrochloride for worsening insomnia (200-600 mg), including the night before admission. Blood-gas analysis of blood from the right corpora was completed and revealed a pH of 6.736, pCO2 of 147, HCO3 of 18.6 and a base excess of 17.7. The patient required aspiration and 560 μg of intracavernosal phenylephrine to achieve sustained detumescence. Emergency physicians should be aware of this risk as priapism is a medical emergency and this is the first report with hydroxyzine after an intentional overdose to our knowledge.Published by Elsevier Inc.

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