• US Preventive Services Task Force, Alex H Krist, Karina W Davidson, Carol M Mangione, Michael Cabana, Aaron B Caughey, Esa M Davis, Katrina E Donahue, Chyke A Doubeni, John W Epling, Martha Kubik, Li Li, Gbenga Ogedegbe, Douglas K Owens, Lori Pbert, Michael Silverstein, James Stevermer, Chien-Wen Tseng, and John B Wong.
• Fairfax Family Practice Residency, Fairfax, Virginia.
• JAMA. 2021 Apr 13; 325 (14): 1436-1442.

ImportanceVitamin D is a fat-soluble vitamin that performs an important role in calcium homeostasis and bone metabolism and also affects many other cellular regulatory functions outside the skeletal system. Vitamin D requirements may vary by individual; thus, no one serum vitamin D level cutpoint defines deficiency, and no consensus exists regarding the precise serum levels of vitamin D that represent optimal health or sufficiency.ObjectiveTo update its 2014 recommendation, the US Preventive Services Task Force (USPSTF) commissioned a systematic review on screening for vitamin D deficiency, including the benefits and harms of screening and early treatment.PopulationCommunity-dwelling, nonpregnant adults who have no signs or symptoms of vitamin D deficiency or conditions for which vitamin D treatment is recommended.Evidence AssessmentThe USPSTF concludes that the overall evidence on the benefits of screening for vitamin D deficiency is lacking. Therefore, the balance of benefits and harms of screening for vitamin D deficiency in asymptomatic adults cannot be determined.RecommendationThe USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of screening for vitamin D deficiency in asymptomatic adults. (I statement).

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