• Thoracic surgery clinics · Aug 2014

    Review

    Peptide receptor radionuclide therapy for advanced neuroendocrine tumors.

    • Lisa Bodei, Marta Cremonesi, Mark Kidd, Chiara M Grana, Stefano Severi, Irvin M Modlin, and Giovanni Paganelli.
    • Division of Nuclear Medicine, European Institute of Oncology, via Ripamonti 435, Milan 20141, Italy. Electronic address: lisa.bodei@ieo.it.
    • Thorac Surg Clin. 2014 Aug 1; 24 (3): 333-49.

    AbstractPeptide receptor radionuclide therapy (PRRT) consists of the systemic administration of a synthetic peptide, labeled with a suitable β-emitting radionuclide, able to irradiate tumors and their metastases via internalization through a specific receptor (usually somatostatin S2), over-expressed on the cell membrane. After almost 2 decades of experience, PRRT, with either (90)Y-octreotide or (177)Lu-octreotate, has established itself to be an efficient and effective therapeutic modality. As a treatment, it is relatively safe up to the known thresholds of absorbed and bio-effective isotope dosages and the renal and hematological toxicity profiles are acceptable if adequate protective measures are undertaken. Copyright © 2014 Elsevier Inc. All rights reserved.

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