• Silvano Esposito, Giuseppe De Simone, Giovanni Boccia, Francesco De Caro, and Pasquale Pagliano.
• Department of Infectious disease, University of Salerno, Salerno, Italy. Electronic address: silvanoesposito@libero.it.
• J Glob Antimicrob Resist. 2017 Sep 1; 10: 204-212.

AbstractSepsis and septic shock are common life-threatening pathologies associated with high mortality and substantial costs for healthcare system. Clinical guidelines and bundles for the management of patients with sepsis have recently been updated. Herein, we review the history of sepsis and related conditions definitions from the first consensus conference in 1991 to nowadays, the epidemiologic data resulting from worldwide studies on incidence and mortality, the diagnostic approaches including the microbiological assessment of infection and the use of several prognostic and diagnostic biomarkers and finally we review the main therapeutic measures as the intravenous immunoglobulin therapy and the administration of appropriate antibiotic treatment to provide patients with sepsis a favourable outcome in the antibiotic-resistance era.Copyright © 2017 International Society for Chemotherapy of Infection and Cancer. Published by Elsevier Ltd. All rights reserved.

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