• Jpn. J. Physiol. · Jan 1990

    Effects of stimulation of cervical sympathetic trunks with various frequencies on the local cortical cerebral blood flow measured by laser Doppler flowmetry in the rat.

    • Y Saeki, A Sato, Y Sato, and A Trzebski.
    • Department of Physiology, Tokyo Metropolitan Institute of Gerontology, Japan.
    • Jpn. J. Physiol. 1990 Jan 1; 40 (1): 15-32.

    AbstractThe effects of electrical stimulation of cervical sympathetic trunks for 1-min duration at supramaximal intensity with various stimulus frequencies on local cortical cerebral blood flow were investigated in urethane-anesthetized rats. Electrical stimulation with low frequency (1-2 Hz) produced a significant increase in local cortical cerebral blood flow during the stimulation. The local cortical CBF reached 111% of the resting value during the stimulation at 10 Hz, and slightly decreased for about 30s after the end of stimulation. High-frequency stimulation (20-30 Hz) produced the short-term increase during the stimulation, which was followed by the dominant and long-lasting decrease, and the local cortical CBF reached 87% (at 30 Hz) of the resting value after the end of stimulation. The response of increase in flow was abolished by intravenous administration of beta adrenergic blocking agent (propranolol, 1.3 mg/kg i.v.), while the response of decrease in flow was abolished by alpha adrenergic blocking agent (phenoxybenzamine, 0.5 mg/kg i.v.).

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