• Yang Hu, Liu-Sheng Wang, Yue-Ping Jin, Shan-Shan Du, Yu-Kui Du, Xian He, Dong Weng, Ying Zhou, Qiu-Hong Li, Li Shen, Fen Zhang, Yi-Liang Su, Xiao-Li Sun, Jing-Jing Ding, Wen-Hui Zhang, Hou-Rong Cai, Hua-Ping Dai, Jing-Hong Dai, and Hui-Ping Li.
• Department of Respiratory Medicine, Shanghai Pulmonary Hospital, The Affiliated Hospital of Tongji University, School of Medicine, Shanghai, China.
• Clin Respir J. 2017 May 1; 11 (3): 337-345.

ObjectivesThe purpose of this study was to determine the diagnostic and prognostic values of serum KL-6 levels in Chinese patients with interstitial lung disease (ILDs).MethodsA total of 1084 subjects including 373 cases of ILDs, 584 cases of non-ILD pulmonary diseases, and 127 healthy individuals were recruited from three clinical centers in China between January 2011 and December 2013. A total of 106 patients undergoing treatments for ILDs in Shanghai Pulmonary Hospital between January 2011 and December 2013 were enrolled. Baseline and posttreatment serum KL-6 levels were determined.ResultsSerum KL-6 levels in patients with ILDs were significantly higher than those in patients with non-ILD pulmonary diseases or in healthy individuals (1492.09 ± 2230.08 U/mL vs 258.67 ± 268.73 U/mL or 178.73 ± 71.17 U/mL, all P < 0.05). At the cut-off value of 500 U/mL, the sensitivity and specificity of serum KL-6 as a diagnostic marker for ILDs was 77.75% and 94.51%, respectively. The Kappa value was 0.743 (P < 0.001). The area below the receiver operating characteristic curve was 0.922 with a 95% Confidence interval of 0.904-0.941 (P < 0.001). The posttreatment serum KL-6 levels significantly reduced in patients with improved ILDs, whereas markedly increased in patients with exacerbated ILDs (All P < 0.05).ConclusionsSerum KL-6 levels might be a promising diagnostic biomarker for ILDs in Chinese patients. The prognostic value of serum KL-6 levels for ILDs remains to be verified by large-scaled studies.© 2015 John Wiley & Sons Ltd.

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