• Dtsch. Med. Wochenschr. · Apr 2021

    Case Reports

    [De novo thombotic microangiopathy (TMA) after incompatible AB0 renal transplantation].

    • Thilo Kolb and Lars Christian Rump.
    • Klinik für Nephrologie, Universitätsklinikum Düsseldorf.
    • Dtsch. Med. Wochenschr. 2021 Apr 1; 146 (8): 530-533.

    HistoryWe report a 57-year-old patient admitted to our hospital for planned AB0-incompatible living kidney transplantation.Findings And DiagnosisOn day 3 post operationem, clear laboratory evidence of de novo TMA developed. Renal detoxification stagnated with initial regular course.Therapy And CourseBy using eculizumab 900 mg on d3 and d10 post operationem, we were able to suppress TMA with a sustained success.ConclusionIt has to be discussed whether an early use of eculizumab in cases of suspected de novo TMA is a safe way to prevent graft dysfunction and thus to improve the poor prognosis for graft and recipient described in the literature.Thieme. All rights reserved.

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