• Dtsch. Med. Wochenschr. · Apr 2021

    Review

    [Bempedoic Acid].

    • Michael Wagner, Julian Leefmann, Stephan R Künzel, Michael M Schmidt, and Ali El-Armouche.
    • Dtsch. Med. Wochenschr. 2021 Apr 1; 146 (8): 552-558.

    AbstractATP-Citrate-Lyase is a key enzyme of cholesterol biosynthesis. Its liver-specific inhibition by the bempedoic acid opens new possibilities to effectively escalate a cholesterol-lowering therapy while avoiding muscle-related side effects. Herein, we present the properties of this new first-in-class pharmaceutical agent and discuss potential consequences for pharmacotherapy.Thieme. All rights reserved.

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