• Int J Med Sci · Jan 2021

    Review

    The role of tumor-associated macrophages in primary hepatocellular carcinoma and its related targeting therapy.

    • Lu Deng, Kang He, Yixiao Pan, Hai Wang, Yi Luo, and Qiang Xia.
    • Department of Liver Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
    • Int J Med Sci. 2021 Jan 1; 18 (10): 2109-2116.

    AbstractLiver macrophages consist of ontogenically distinct populations termed Kupffer cells and monocyte-derived macrophages. Tumor-associated macrophages (TAMs) inhepatocellularcarcinoma (HCC) play a prominent role in tumormicroenvironment by presenting M1(induced by IFN γ along with LPS) and M2(induced by IL-4 and IL13) polarization. Although TAMs are involved in tumor immune surveillance during the course of HCC, they contribute to tumour progression at different levels by inhibiting the anti-tumor immune response, promoting the generation of blood vessels and lymphatic vessels, and supporting the proliferation and survival of tumor cells. In this paper, the multiple functions of TAMs in HCC were reviewed to provide assistance for future researches about therapeutic approaches.© The author(s).

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