• Daniel Camprubí-Ferrer, Aránzazu Portillo, Sonia Santibáñez, Alejandro Almuedo-Riera, Natalia Rodriguez-Valero, Carme Subirà, Miguel J Martinez, Jessica Navero-Castillejos, Marc Fernandez-Pardos, Blaise Genton, Ludovico Cobuccio, Steven Van Den Broucke, Emmanuel Bottieau, Jose Muñoz, and José Antonio Oteo.
• ISGlobal, Hospital Clínic-Universitat de Barcelona, 08036 Barcelona, Spain.
• J Travel Med. 2021 Jun 1; 28 (4).

BackgroundAlthough tick-borne pathogens have been reported as an important cause of imported fever, the incidence of Anaplasma phagocytophilum, the causative agent of human granulocytic anaplasmosis (HGA), in travellers is unknown.MethodsWe conducted a prospective cohort study to investigate the aetiologies of fever in returning travellers (November 2017-July 2019). Polymerase chain reaction for msp2 gene amplification and indirect immunofluorescence assay for A. phagocitophilum were performed in all returning travellers with undifferentiated non-malarial fever.ResultsAmong 141 travellers included, 8 patients were diagnosed with probable or confirmed HGA. The overall incidence rate of HGA was 19.9 cases/1000 person-week of travel. The main destination of travel was Asia, accounting for 62.5% patients with HGA. Co-infections were found in 37.5% of patients with HGA.ConclusionsDiagnosis of HGA and empirical treatment with doxycycline should be considered in travellers with fever.© International Society of Travel Medicine 2021. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

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