• Annals of medicine · Aug 2011

    Review

    Autoinflammatory diseases and cardiovascular manifestations.

    • Donato Rigante, Luca Cantarini, Massimo Imazio, Orso Maria Lucherini, Emanuela Sacco, Mauro Galeazzi, Maria Giuseppina Brizi, and Antonio Brucato.
    • Department of Pediatric Sciences, Università Cattolica Sacro Cuore, Rome, Italy. drigante@gmail.com
    • Ann. Med. 2011 Aug 1; 43 (5): 341-6.

    AbstractAbstract A host of clinical scenarios can be depicted in hereditary autoinflammatory diseases, and the cardiovascular system can also be involved especially in familial Mediterranean fever (FMF), caused by mutations in the MEFV gene, and tumour necrosis factor receptor-associated periodic syndrome (TRAPS), caused by mutations in the TNFRSF1A gene. Pericardial diseases are the most represented cardiovascular abnormalities, though the role of MEFV and TNFRSF1A in the initiation of heart involvement has not been demonstrated formally and will be discussed herein.

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