• Sofia Waissbluth, Karina Lira, Karina Aracena, Javier Oyarzun, Matias Willson, and Cristián Seiltgens.
• Department of Otorhinolaryngology, UC Christus Health Center, Pontificia Universidad Católica de Chile, Chile.
• Rev Med Chil. 2020 Dec 1; 148 (12): 1781-1786.

BackgroundOsteogenesis imperfecta (OI) is a rare group of genetic disorders affecting connective tissue, with consequent bone fragility, frequent fractures and skeletal deformity. Depending on the type, patients can have blue sclera, dentinogenesis imperfecta, and hearing loss.AimTo determine the frequency, type and audiometric characteristics of hearing loss in a group of patients with OI.Material And MethodsA prospective cohort study was completed. A clinical and diagnostic hearing evaluation with tympanometry, acoustic stapedial reflex, pure-tone and speech audiometry were performed.ResultsThirty patients completed the study; mean age of 22 years (range 6-63 years). Sixty seven percent had a type I OI. Overall, nine (30%) patients had hearing loss (15/60 ears). Of these, six had bilateral hearing loss. Of the 15 affected ears, six showed conductive hearing loss, five sensorineural hearing loss, and four mixed hearing loss. Patients with hearing loss were older than patients with normal hearing. Only one pediatric patient developed hearing loss. Of the ears without hearing loss, 13% did not have an acoustic stapedial reflex.ConclusionsIn this group of patients with OI, 30% had hearing loss and among those ears with normal hearing, 13% did not have an acoustic stapedial reflex. Patients with OI should be monitored for hearing loss.

20 keywords...

hide…