• Tomoyuki Asano, Yuzuka Saito, Naoki Matsuoka, Jumpei Temmoku, Yuya Fujita, Kasumi Hattori, Shunsuke Kobayashi, Akira Ojima, Toshiyuki Takahashi, Haruki Matsumoto, Makiko Yashiro-Furuya, Shuzo Sato, Hiroko Kobayashi, Hiroshi Watanabe, Kiori Yano, Tomomi Sasajima, Kazuo Fujihara, and Kiyoshi Migita.
• Department of Rheumatology.
• Medicine (Baltimore). 2021 Apr 16; 100 (15): e24889e24889.

RationaleAnti-myelin oligodendrocyte protein antibody-associated disease (MOGAD) is a new disease entity with various clinical phenotypes. MOGAD often present with recurrent optic neuritis (ON), and it can also develop as a compartment of neuromyelitis optica spectrum disorder (NMOSD). Moreover, multiple autoantibodies such as an anti-myeloperoxidase antineutrophil cytoplasmic antibody (MPO-ANCA) had been reported in the serum of patients with NMOSD.Patient ConcernsWe report an 86-year-old woman with a 2-year history of microscopic polyangiitis (MPA). The patient had a rapid loss of vision in her left eye. No abnormal findings were observed on her left fundus, and she tested negative for MPO-ANCA upon admission. However, anti-MOG antibodies were observed in the patient's serum and cerebrospinal fluid.DiagnosisA diagnosis of MOGAD complicated with MPA was made.InterventionsThe patient received twice steroid pulse therapy and oral azathioprine as maintenance therapy.OutcomesHer vision rapidly recovered, and no subsequent relapse was observed during the 8-month observation period.ConclusionTo the best of our knowledge, this is the first case of MOGAD complicated with MPA, and steroid pulse therapy and azathioprine therapy were effective for ON caused by MOGAD.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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