• Kenichi Yamamuro, Atsushi Seichi, Atsushi Kimura, Ichiro Kikkawa, Masahiro Kojima, Hirokazu Inoue, and Yuichi Hoshino.
• Department of Orthopedics, Faculty of Medicine, Jichi Medical University, Tochigi, Japan.
• Spine. 2012 Oct 15; 37 (22): E1398-401.

Study DesignHistological observational study of patients with spinal meningioma.ObjectiveTo clarify the status of tumor cell invasion into the dura mater and to provide fundamental information for appropriate management of dural attachment.Summary Of Background DataHistological appearance of the dura attached to spinal meningioma has not been sufficiently evaluated.MethodsDura mater resected in a Simpson Grade 1 manner from 25 consecutive patients with spinal meningiomas (World Health Organization grade 1) was histologically observed to determine the status of tumor cell invasion. As no clear borders such as a tumor capsule between tumor and dura mater were observed, histological findings of the dura mater were classified into the following 3 categories: grade 1, no dural invasion, with only inflammation of the dura; grade 2: dural invasion below the zone between the inner and outer layers; and grade 3, dural invasion into or over the zone between the inner and outer layers (full-thickness invasion).ResultsIn our microscopic study, 19 of the 25 cases of spinal meningioma showed evidence of dural invasion and 15 cases showed full-thickness invasion.ConclusionThis histological investigation of resected dura mater attached to spinal meningioma showed a high rate of full-thickness tumor invasion into the dura mater.

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