• Nursah Basol, Atac Celik, Nevin Karakus, Sibel Demir Ozturk, Sibel Demir Ozsoy, and Serbulent Yigit.
• Gaziosmanpasa University, Faculty of Medicine, Department of Emergency Medicine, Tokat, Turkey drnursahbs@hotmail.com nursahbsl@gmail.com.
• In Vivo. 2014 Sep 1; 28 (5): 983-7.

Background/AimGenetic polymorphism is a strong risk factor for coronary artery disease (CAD). In the present study, our aim was to evaluate angiotensin-converting enzyme (ACE) gene I/D polymorphism and interleukin-4 (IL-4) gene Intron 3 variable number of tandem repeat (VNTR) polymorphism in CAD.Materials And MethodsOne hundred and twenty-four CAD patients and one hundred and twenty-three controls were enrolled. Genomic DNA was isolated and genotyped using polymerase chain reaction (PCR) analyses.ResultsThe risk associated with inheriting the combined genotypes for the two polymorphisms were evaluated and it was found that the individuals who were P2P2-homozygous at IL-4 gene intron 3 VNTR and DD-homozygous at ACE gene I/D have a higher risk of developing CAD.ConclusionAlthough, there is no correlation between IL4 VNTR polymorphism and ACE gene polymorphism and CAD, there is a strong association between CAD and co-existence of IL-4 VNTR and ACE gene polymorphisms in the Turkish population.Copyright © 2014 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.

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