• Ilona Bobek, László Gopcsa, Marienn Réti, Gabriella Bekő, Lilla Hancz, Botond Lakatos, Eszter Molnár, Sándor Nagy, Péter Reményi, Gabriella Sebestyén, János Sinkó, János Szlávik, Miklós Szolnoky, and István Vályi-Nagy.
• Intenzív Terápiás Osztály,Dél-pesti Centrumkórház, Országos Hematológiai és Infektológiai Intézet, Budapest.
• Orv Hetil. 2020 Jul 1; 161 (27): 1111-1121.

IntroductionAt present, neither specific curative treatment nor vaccines for novel coronavirus 2019 (COVID-19) are available. There is an urgent need to look for alternative strategies for COVID-19 treatment especially in the case of severe and/or critically ill patients with cytokine release syndrome (CRS).AimConvalescent plasma proved to increase survival rates in other severe viral infections. Therefore, convalescent plasma could be a promising treatment option for severe COVID-19 patients.MethodIn our article, we present the first two critically ill Hungarian patients with COVID-19 infection treated with convalescent fresh frozen plasma.ResultsAt the time of plasma therapy both patients were on mechanical ventilation and received antiviral agents and a full scale of supportive care. Each patient received 3 × 200 mL of convalescent plasma of recently recovered donors with sufficient novel anti-coronavirus IgG titers. Subsequent to convalescent plasma infusion, oxygenization improved and inflammatory markers decreased in both individuals. As compared to pretransfusion, lymphocyte counts increased and interleukin-6 level lessened. Both patients were weaned from mechanical ventilation within 2 weeks of treatment. No severe adverse effects were observed.ConclusionsOur experience indicates that convalescent plasma therapy is well tolerated and could potentially improve clinical outcomes. Optimal dose and timing as well as precise assessment of clinical benefit of convalescent plasma therapy will need further investigation in larger, well-controlled trials. This is the first report of the successful use of convalescent plasma in the treatment of critically ill patients with COVID-19 infection in Hungary. Orv Hetil. 2020; 161(27): 1111-1121.

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