• Ideggyogy Szemle · Jul 2017

    Case Reports

    [Systemic thrombolysis after the administration of idarucizumab in acute ischemic stroke].

    • Máté Pásztor, Dániel Bereczki, Zoltán Szakács, and Zsolt May.
    • Magyar Honvédség Egészségügyi Központ, Neurológiai Osztály, Budapest.
    • Ideggyogy Szemle. 2017 Jul 30; 70 (7-8): 284-288.

    AbstractIntroduction - Expanding indications have resulted in an increasing number of patients taking novel oral anticoagulants, posing a major treatment dilemma in acute ischemic stroke. Case presentation - We present a successful intravenous thrombolysis in a dabigatran-treated patient with acute ischemic stroke after the administration of idarucizumab. Discussion - According to current guidelines, systemic thrombolysis is contraindicated under treatment with novel oral anticoagulants (taken within 48 hours). In this scenario, idarucizumab offers a solution by reversing the anticoagulant effect of dabigatran. Conclusion - Although there have only been case reports published so far, the dabigatran-antidote idarucizumab seems to give new therapeutic opportunities in the treatment of acute ischemic stroke.

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