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Chin. J. Traumatol. · Feb 2008
ReviewS100B protein and its clinical effect on craniocerebral injury.
- Xue-song Yuan and Xiao-xing Bian.
- Department of Neurosurgery, Affiliated Wujin Hospital, Jiangsu University, Wujin 213002, China. cedar.y@163.com
- Chin. J. Traumatol. 2008 Feb 1; 11 (1): 54-7.
ObjectiveTo explore the role of S100B protein in the early diagnosis, treatment, and prognosis judgement of craniocerebral injury.MethodsIn this study, we reviewed the domestic and foreign research reports about the relationship between S100B protein and craniocerebral injury.ResultsThe concentration of S100B protein had a different increase based on the degree of injury in early stage after craniocerebral injury, and the increasing degree of S100B protein showed a positive correlation with the grading of pathogenetic condition and prognosis of craniocerebral injury.ConclusionsS100B protein may be taken as a specific index of early diagnosis, grading of pathogenetic condition, and prognosis judgement after craniocerebral injury. To grasp and regulate the mechanism of neurotoxicity and to elucidate the therapeutic effect of S100B protein will be a research direction in clinical treatment of craniocerebral injury.
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