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J. Infect. Chemother. · Apr 2006
Clinical TrialSingle dose of cefodizime completely eradicated multidrug-resistant strain of Neisseria gonorrhoeae in urethritis and uterine cervicitis.
- Tetsuro Matsumoto, Tetsuro Muratani, Koichi Takahashi, Yukiko Ando, Yumiko Sato, Masako Kurashima, Daisuke Yokoo, Toshihiro Ikuyama, Hiroshi Shimokawa, and Shigeaki Yanai.
- Department of Urology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan. t-matsu@med.uoeh-u.ac.jp
- J. Infect. Chemother. 2006 Apr 1; 12 (2): 97-9.
AbstractCefodizime (CDZM) has strong antimicrobial activity to Neisseria gonorrhoeae in vitro. However, multidrug-resistant N. gonorrhoea emerged and has been increasing in Japan. To know the effectiveness of CDZM on gonococcal urethritis and uterine cervicitis even in the era of multidrug-resistant N. gonorrhoeae, a clinical trial of single-dose therapy of CDZM for gonococcal urethritis and uterine cervicitis was conducted. N. gonorrhoeae was eradicated from 100% of patients with gonococcal urethritis and uterine cervicitis by a single dose of CDZM. In conclusion, CDZM is one of most suitable drugs for the treatment of gonococcal genital infection in the era of multidrug-resistant N. gonorrhoeae.
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