• Gac Med Mex · Jan 2020

    Association of neutrophil-to-lymphocyte and lymphocyte-to-C-reactive protein ratios with COVID-19-related mortality.

    • Alejandra Albarrán-Sánchez, Ricardo D González-Ríos, Paolo Alberti-Minutti, Maura E Noyola-García, Carlos E Contreras-García, Juan C Anda-Garay, Luis E Martínez-Ascencio, David J Castillo-López, Luis A Reyes-Naranjo, Luis A Guízar-García, Guillermo Flores-Padilla, and Claudia Ramírez-Rentería.
    • Department of Internal Medicine.
    • Gac Med Mex. 2020 Jan 1; 156 (6): 553-558.

    IntroductionNeutrophil-to-lymphocyte (NLR) and lymphocyte-to-C-reactive protein (LCR) ratios are used to predict severity and mortality in various infections.ObjectiveTo establish the best NLR and LCR cutoff point to predict mortality in patients hospitalized for COVID-19 in Mexico.MethodAnalytical cross-sectional study of patients hospitalized for severe COVID-19 in a specialty hospital.ResultsOut of 242 analyzed patients, 34 % died. The deceased subjects were older (62 vs. 51 years; p < 0.001), had a higher prevalence of > 10 years with systemic arterial hypertension (59.4 vs. 45.1 %, p = 0.022), as well as a higher NLR (17.66 vs. 8.31, p < 0.001) and lower LCR (0.03 vs. 0.06, p < 0.002) with regard to those who survived. The cutoff points to predict mortality were NLR > 12 and LCR < 0.03. The combination of NLR/LCR had a sensitivity of 80 %, specificity of 74 %, positive predictive value of 46.15 %, negative predictive value of 93.02 % and an odds ratio of 11.429 to predict mortality.ConclusionNLR > 12 and LCR < 0.03 are useful biomarkers to evaluate the risk of mortality in Mexican patients with severe COVID- 19.IntroducciónLos índices neutrófilo/linfocito (INL) y linfocito/proteína C reactiva (ILR) se usan para predecir severidad y mortalidad en diversas infecciones.ObjetivoEstablecer en México el mejor punto de corte de INL e ILR para predecir la mortalidad en pacientes hospitalizados por COVID-19.MétodoEstudio transversal analítico de pacientes hospitalizados por COVID-19 grave en un hospital de especialidades.ResultadosFalleció 34 % de 242 pacientes analizados. Los sujetos fallecidos tenían mayor edad (62 versus 51 años, p < 0.001), mayor prevalencia de hipertensión arterial sistémica > 10 años (59.4 versus 45.1 %, p = 0.022), así como INL más alto (17.66 versus 8.31, p < 0.001) e ILR más bajo (0.03 versus 0.06, p < 0.002) respecto a quienes sobrevivieron. Los puntos de corte para predecir mortalidad fueron INL > 12 e ILR < 0.03. La combinación de INL e ILR tuvo sensibilidad de 80 %, especificidad de 74 %, valor predictivo positivo de 46.15 %, valor predictivo negativo de 93.02 % y razón de momios de 11.429 para predecir la mortalidad.ConclusiónINL > 12 e ILR < 0.03 son biomarcadores útiles para evaluar el riesgo de mortalidad en pacientes mexicanos con COVID-19 grave.Copyright: © 2020 Permanyer.

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