• Gac Med Mex · Jan 2020

    Factors associated with death in children with COVID-19 in Mexico.

    • Rodolfo Rivas-Ruiz, Ivonne A Roy-García, Kingston R Ureña-Wong, Felipe Aguilar-Ituarte, AndaGilberto F Vázquez-deGFVFaculty of Medicine, Universidad Autónoma del Estado de México, State of Mexico., Pedro Gutiérrez-Castrellón, Javier Mancilla-Ramírez, and Sarbelio Moreno-Espinosa.
    • Center for Training in Clinical Research, Research Development Division, Instituto Mexicano del Seguro Social, Mexico City.
    • Gac Med Mex. 2020 Jan 1; 156 (6): 516-522.

    IntroductionMost children affected by SARS-CoV-2 are reported to be asymptomatic, and COVID-19-related mortality in them is low; in Mexico, there is a lack of information on the subject in this population group.ObjectiveTo assess the risk factors associated with mortality in Mexican children with COVID-19.MethodSecondary analysis of the General Directorate of Epidemiology database. Children younger than 19 years, in whom SARS-CoV-2 infection was confirmed by RT-PCR, were included.Results1443 children were included. Median age was eight years; 3.3 % were admitted to the intensive care unit, 1.8 % required assisted mechanical ventilation, and mortality was 1.9 %. In multivariate models, the development of pneumonia was the main risk factor for mortality, with an odds ratio (OR) of 6.45 (95 % CI: 1.99, 20.89); patients who required intubation had an OR of 8.75 (95 % CI: 3.23, 23.7).ConclusionsChildren with COVID-19 exhibit high mortality in Mexico, and avoiding pneumonia should therefore be tried in them, especially in children younger than four years, with cardiovascular risk or immunosuppression.IntroducciónSe informa que la mayoría de los niños afectados por SARS-CoV-2 cursan asintomáticos y que en ellos la mortalidad por COVID-19 es baja; en México se desconoce la información al respecto en este grupo de la población. ­.ObjetivoEvaluar los factores de riesgo asociados a mortalidad en niños mexicanos con COVID-19.MétodoAnálisis secundario de la base de datos de la Dirección General de Epidemiología. Se incluyeron niños menores de 19 años, en quienes se confirmó SARS-CoV-2 mediante RT-PCR.ResultadosSe incluyeron 1443 niños. La mediana de edad fue de ocho años; 3.3 % ingresó a la unidad de cuidados intensivos, 1.8 % requirió ventilación mecánica asistida y la mortalidad fue de 1.9 %. En los modelos multivariados, el desarrollo de neumonía constituyó el principal factor de riesgo de mortalidad, con razón de momios (RM) de 6.45 (IC 95 % 1.99, 20.89); los pacientes que requirieron intubación tuvieron RM de 8.75 (IC 95 % 3.23, 23.7).ConclusionesLos niños con COVID 19 tienen alta mortalidad en México, por lo que en ellos se debe procurar evitar la neumonía, especialmente en los menores de cuatro años, con riesgo cardiovascular o inmunosupresión.Copyright: © 2020 Permanyer.

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