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Br J Clin Pharmacol · Jan 1989
Randomized Controlled Trial Clinical TrialEffect of oral activated charcoal on quinine elimination.
- D Lockey and D N Bateman.
- Wolfson Unit of Clinical Pharmacology, The University, Newcastle upon Tyne.
- Br J Clin Pharmacol. 1989 Jan 1; 27 (1): 92-4.
AbstractThe effect of repeated dose oral activated charcoal on quinine elimination has been studied following a therapeutic (600 mg) dose of quinine bisulphate to seven normal volunteers. Activated charcoal lowered quinine half-life from 8.23 +/- 0.57 s.d. h to 4.55 +/- 0.15 s.d. h (P less than 0.001) and increased its oral clearance by 56%. Activated charcoal may have a role in the management of quinine poisoning.
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