• Ned Tijdschr Geneeskd · Jan 2012

    Review

    [The stepped wedge design].

    • Olaf M Dekkers.
    • Leids Universitair Medisch Centrum, afd. Klinische epidemiologie, Leiden, the Netherlands. o.m.dekkers@lumc.nl
    • Ned Tijdschr Geneeskd. 2012 Jan 1; 156 (9): A4069.

    AbstractNot all questions concerning therapeutic effects in medical research can be answered satisfactorily by standard trials. The stepped wedge cluster design is a special form of randomised study in which an intervention at group level is implemented in stages. The design can be used in situations where randomization at the patient level is inappropriate or impossible and where a stepped implementation of the experimental intervention is important for ethical, logistic or financial reasons. The time before the experimental intervention is introduced in a cluster is used as control period. The statistical analysis of cluster trials should account for the fact that individuals within clusters may show many similarities. Ethical aspects of stepped wedge design should be considered carefully, especially when obtaining individual informed consent is not possible.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…