• Nieke Zhang, Xiaoyan Wang, Chunying Wang, Shuqiu Chen, Jianping Wu, Guangyuan Zhang, Weidong Zhu, Jing Liu, Bin Xu, Mulong Du, and Ming Chen.
• Department of Urology, Affiliated Zhongda Hospital of Southeast University, Nanjing, China.
• Front Oncol. 2019 Jan 1; 9: 981.

AbstractPurpose: Evaluate the diagnostic accuracy of multi-parametric magnetic resonance imaging (mp-MRI) for local staging of bladder cancer (BCa). Materials and Methods: The databases of PubMed, Web of Science, Wanfang, and CNKI were searched for related literatures about BCa diagnosed by mp-MRI from January 1, 2000 to April 12, 2019. The strict inclusion and exclusion criteria were set up to extract records. The Quality Assessment of Diagnostic Accuracy Studies (QUADAS)-2 was used to evaluate quality of the candidate studies. The pooled sensitivity, specificity, positive likelihood ratio (+LR), negative likelihood ratio (-LR), and diagnostic odds ratio (DOR) were calculated to assess the diagnostic authenticity of mp-MRI. The summarized receiver operating characteristic (SROC) curve corresponding with the area under the curve (AUC) were analyzed to comprehensively evacuate the diagnostic value of mp-MRI. Results: A total of 140 studies were retrieved by computer-based searching. After quality control, 4 studies with 259 patients were enrolled for meta-analysis. The pooled results showed 0.84 of sensitivity [95% confidence interval (CI) = 0.79-0.89], 0.91 of specificity (95% CI = 0.87-0.93), 8.24 of +LR (95% CI = 4.87-13.92), 0.18 of -LR (95% CI = 0.10-0.31), 49.42 of DOR (95% CI = 19.07-128.09), and 0.946 of AUC. The Spearman correlation analysis found no threshold effect (p = 0.684). A significant heterogeneity existed among 4 included studies with sensitivity (I2 = 65.7%), specificity (I2 = 60.0%) and diagnostic OR (I2 = 67.5%). The Begg's test (p = 0.497) and the egger's test (p = 0.337) found no publication bias. Conclusion: mp-MRI acts a good diagnostic performance for bladder cancer. It is plausible that mpMRIs can be used as an important method for bladder cancer staging.Copyright © 2019 Zhang, Wang, Wang, Chen, Wu, Zhang, Zhu, Liu, Xu, Du and Chen.

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