• T A Berninger and W Heider.
• Max-Planck-Institut für Physiologische, Bad Nauheim, Federal Republic of Germany.
• Graefes Arch. Clin. Exp. Ophthalmol. 1990 Jan 1; 228 (5): 410-4.

AbstractA total of 20 patients with unilateral acute optic neuritis were studied. Each patient had experienced the recent onset of a decrease in visual acuity, a relative afferent pupillary defect, a relative or absolute central scotoma and a colour-vision defect. The pattern-reversal electroretinogram (PERG) of each patient was analysed with regard to the amplitude of the positive and negative components. During the acute stage the amplitude of the positive component was reduced in all patients and that of the negative, in 18 of 20 cases. Parallel to clinical recovery, a steady increase was observed in the amplitude of the positive component to normal values; no statistical differences between affected and fellow eyes was found. In contrast, the amplitude of the negative component remained significantly reduced after clinical recovery.

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