• Giuseppe A Ramirez, Enrica P Bozzolo, Agnese Gobbi, Elena Castelli, Clarissa Centurioni, Mattia DI Meo, Della TorreEmanuelEUnit of Immunology, Rheumatology, Allergy and Rare Diseases, IRCCS San Raffaele Hospital, Milan, Italy.Vita-Salute San Raffaele University, Milan, Italy., Flavia DI Scala, Anna Morgillo, Alessandro Marinosci, Martina Miglio, Paolo Scarpellini, Chiara Tassan Din, Barbara Castiglioni, Chiara Oltolini, Marco Ripa, Gaetano DI Terlizzi, Valentina DA Prat, Sarah Damanti, Raffaella Scotti, Giuseppe DI Lucca, Martina Baiardo Redaelli, Valentina P Plumari, Elena Moizo, Francesco Carcó, Paolo Silvani, Francesco DE Cobelli, Giovanni Landoni, Moreno Tresoldi, and COVID-BioB group.
• Unit of Immunology, Rheumatology, Allergy and Rare Diseases, IRCCS San Raffaele Hospital, Milan, Italy - ramirez.giuseppealvise@hsr.it.
• Panminerva Med. 2022 Dec 1; 64 (4): 506516506-516.

BackgroundNon-invasive mechanical ventilation (NIV) is effective for symptom relief and respiratory support in patients with respiratory insufficiency, severe comorbidities and no indication to intubation. Experience with NIV as the ceiling of treatment in severely compromised novel coronavirus disease (COVID-19) patients is lacking.MethodsWe evaluated 159 patients with COVID-19-related acute respiratory syndrome (ARDS), 38 of whom with NIV as the ceiling of treatment, admitted to an ordinary ward and treated with continuous positive airway pressure (CPAP) and respiratory physiotherapy. Treatment failure and death were correlated with clinical and laboratory parameters in the whole cohort and in patients with NIV as the ceiling of treatment.ResultsPatients who had NIV as the ceiling of treatment were elderly, with a low BMI and a high burden of comorbidities, showed clinical and laboratory signs of multiorgan insufficiency on admission and of rapidly deteriorating vital signs during the first week of treatment. NIV failure occurred overall in 77 (48%) patients, and 27/38 patients with NIV as the ceiling of treatment died. Congestive heart failure, chronic benign hematological diseases and inability/refusal to receive respiratory physiotherapy were independently associated to NIV failure and mortality. Need for increased positive end-expiratory pressures and low platelets were associated with NIV failure. Death was associated to cerebrovascular disease, need for CPAP cycles longer than 12 h and, in the subgroup of patients with NIV as the ceiling of treatment, was heralded by vital sign deterioration within 48 h.ConclusionsNIV and physiotherapy are a viable treatment option for patients with severe COVID-19 and severe comorbidities.

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