• Jorge-Ignacio Martinez, Hector-Fabio Sánchez, Julio-Alberto Velandia, Zulma Urbina, María-Cristina Florián, Mauricio-Antonio Martínez, Evangelos J Giamarellos-Bourboulis, Carmen-Juliana Pino-Pinzón, Guillermo Ortiz, and Edgar Celis.
• Medical Director Critical Medicine and Intensive Care Service, San Pedro Hospital Foundation, Pasto, Nariño, Colombia.
• J Crit Care. 2021 Aug 1; 64: 120-124.

AbstractThe therapeutic potential of IgM-enriched immunoglobulin preparations (IgGAM) in sepsis remains a field of debate. The use of polyclonal immunoglobulins as adjuvant therapy (Esen & Tugrul, 2009; Kaukonen et al., 2014; Molnár et al., 2013; Taccone et al., 2009) has been shown to improve clinical outcomes in terms of mortality. This study analyze the impact of IgM-enriched IgG (IgGM) as additional immunomodulation. Patients and methods: This is a retrospective registry of 1196 patients with severe sepsis and septic shock from nine Intensive Care Units in Colombia, from routine clinical practice; 220 patients treated with IgGAM were registered. Fully matched comparators for severity and type of infection selected among patients non-treated with IgGAM. Mortality after 28 days was 30.5% among IgGAM-treated patients and 40.5% among matched comparators. Results: Multivariate Cox regression analysis showed IgGAM treatment to be the only variable protective from death after 28 days (hazard ratio 0.62; 0.45-0.86; p: 0.004). Results reinforce the importance of IgGAM treatment for favorable outcome after septic shock and are in line with recent published meta-analyses. This study showed that treatment with IgGM in patients with sepsis was an independent modulator of the 28-day associated with a lower mortality.Copyright © 2021 Elsevier Inc. All rights reserved.

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