• Zhong Nan Da Xue Xue Bao Yi Xue Ban · Oct 2020

    Research progress in nervous system damage caused by SARS-CoV-2.

    • Peng Huang, Li Tang, Yi Ren, and Liqun Liu.
    • Department of Pediatrics, Second Xiangya Hospital, Central South University, Changsha 410011. 188212179@csu.edu.cn.
    • Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2020 Oct 28; 45 (10): 1247-1254.

    AbstractThe coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a major outbreak in the world. SARS-CoV-2 infection can not only involve in the respiratory system, but also cause severe nervous system damage. Studies have shown that SRAS-CoV-2 can invade the nervous system through hematogenous and transneuronal pathways, and may cause nervous system damage in patients with COVID-19 by inhibiting cellular immunity, hypoxemia, inflammation, inducing neuronal degeneration and apoptosis, and angiotensin converting enzyme 2 (ACE2) mechanism. It can lead to intracranial infection, toxic encephalopathy, acute cerebrovascular disease, muscle damage, peripheral nervous system injury, acute myelitis, demyelination disease or other nervous system diseases.

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