• Medicine · Apr 2021

    Meta Analysis

    The therapeutic effect and safety of the drugs for COVID-19: A systematic review and meta-analysis.

    • Rong Qiu, Jingwei Li, Yuxuan Xiao, Ziyi Gao, Yihang Weng, Qiran Zhang, Chengdi Wang, Hanlin Gong, and Weimin Li.
    • Department of Respiratory and Critical Care Medicine.
    • Medicine (Baltimore). 2021 Apr 23; 100 (16): e25532e25532.

    BackgroundCoronavirus disease 2019 (COVID-19) has spread almost all regions of the world and caused great loss to the whole body of mankind. Thus, numerous clinical trials were conducted to find specific medicine for COVID-19 recently. However, it remains unanswered whether they are beneficial.ObjectiveThis study aimed to evaluate the efficiency and safety of the COVID-19 medicine.MethodsStudies were determined through searching PubMed, Embase, Cochrane Library, and Medline. The studies of COVID-19 medicine were involved with eligible end points containing mortality, discharge rate, rate of clinical improvement, and rate of serious adverse events.ResultsA total of 33 studies involving 37,879 patients were included in our study, whose intervening measures contained three major types of COVID-19 medicine, ACEI/ARB, antiviral medicine, and chloroquine/hydroxychloroquine. Compared to control group, COVID-19 drugs have no distinct effect on mortality (RR, 0.93; 95% CI, 0.79-1.11, P = .43) and discharge rate (RR, 1.06; 95% CI, 0.98-1.14, P = .13). However, antiviral medicine presents the obvious advantage in clinical improvement (RR, 1.11; 95% CI, 1.01-1.23, P < .05). In addition, the serious adverse events rate (RR, 0.75; 95% CI, 0.63-0.88, P < .05) of COVID-19 medicine is lower than control group.ConclusionThe results indicated antiviral medicine was potential specific medicine for COVID-19 treatment by improving clinical symptoms, but it failed to increase the discharge rate and reduce mortality. Chloroquine/hydroxychloroquine and ACEI/ARB had no significant effect on treatment of COVID-19, thus they were not recommended for routine medication. Moreover, more trials are needed to find effective drugs to lower the mortality of COVID-19 patients.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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