• Medicine · Apr 2021

    Observational Study

    Low levels of anti-cyclic citrullinated peptide (CCP) 3.1 associated with diseases other than rheumatoid arthritis.

    • James J Son, Mariko Ishimori, James Mirocha, Michael H Weisman, and Lindsy J Forbess.
    • Department of Internal Medicine.
    • Medicine (Baltimore). 2021 Apr 23; 100 (16): e25558e25558.

    AbstractOur aim was to investigate the newest generation anti-cyclic citrullinated peptide (CCP) antibody 3.1 assay in diagnosing rheumatoid arthritis (RA) compared with other autoimmune and non-autoimmune diseases. We performed a retrospective observational chart review of patients with a positive CCP level over a one-year period at a single academic institution and assessed the associated diagnoses after at least six-months of follow-up. Of the 281 CCP positive patients during that period, 48% had a diagnosis of RA. The positive predictive value of RA in patients with a high CCP 3.1 assay was 0.619 compared to 0.248 with a low positive CCP 3.1 assay (P < .0001). Overall, there was a lower than expected positive predictive value of CCP 3.1 level with an RA diagnosis, though the likelihood of having an RA diagnosis was higher with a higher CCP level.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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