• Cheng-Ying Qiu, Zao-Xia Guo, Gui-Hua Zhang, Yong-Hong Feng, Ying-Yun Deng, Xian-Jia Chen, Xiao-Dong Wu, and Shan-Wen Huang.
• Department of Pediatrics, Sanya People 's Hospital, No. 558 Jiefang Road, Tianya District, Sanya City.
• Medicine (Baltimore). 2021 Apr 23; 100 (16): e25593e25593.

BackgroundTo systematically evaluate the effectiveness and safety of traditional Chinese medicine preparation XPYEG combined with SBI and SBI alone in the treatment of REC, and to provide the reference in drugs for the clinical treatment of children with rotavirus enteritis.MethodsRetrieving the English databases: PubMed, Cochrane Library and Embase; Chinese databases: CNKI, CBM and WANFANG Data. Retrieving a randomized controlled trial of XPYEG and SBI in the treatment of REC. The retrieval time is from the above database until September 2020. The retrieval strategy of combining free words and subject words is adopted, and the references included in the literature are searched manually in accordance with the literature studied in this paper and not included in the above database. Two researchers screen the literature according to the literature inclusion and exclusion criteria, extract valid data and evaluate the quality of the literature, and cross-check it. Using the RevMan 5.3 software to conduct the meta-analysis on the main outcome and secondary outcome indicators of the included literature, while assessing the evidence quality of included study.ResultsThe effectiveness and safety of XPYEG and SBI in the treatment of REC are presented through the main and secondary outcome indicators.Osf Registration NumberDOI 10.17605/OSF.IO/3QSZG.ConclusionThis study will conclude whether the combination of XPYEG and SBI is more effective than SBI alone in the treatment of REC, and whether the medication increases the risk of adverse reactions compared with single medication.Ethics And DisseminationThis study does not involve the specific patients, and all research data comes from publicly available professional literature, so an ethics committee is not required to conduct an ethical review and approval of the study.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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