• Yufeng Deng, Luqi Hou, Dianyue Qin, Ting Huang, and Tianzhu Yuan.
• Department of Cardiothoracic Surgery.
• Medicine (Baltimore). 2021 Apr 23; 100 (16): e25600e25600.

BackgroundEsophageal perforation has been one of the serious clinical emergencies, because of the high mortality and complication rates. However, the current prognosis of esophageal perforation and the outcomes of available treatment methods are not well defined. This study attempted to pool the immediate outcomes of esophageal perforation in the past 2 decades.MethodsThe clinical data of 22 consecutive adult patients with esophageal perforation in our center were analyzed. A pooled analysis was also conducted to summarize results from the literatures published between 1999 and 2020. Studies that met the inclusion criteria were assessed, and their methodological quality was examined.ResultsThe mortality and complication rates in our center were 4.55% and 31.82%, separately. The pooled analysis included 45 studies published between 1999 and 2019, which highlighted an overall immediate mortality rate of 9.86%. Surgical treatments were associated with a pooled immediate mortality of 10.01%, and for conservative treatments of 6.49%. Besides, in the past decade, the mortality and complication rates decreased by 27.12% and 46.75%, respectively.ConclusionsIn the past 2 decades, the overall immediate mortality rate of esophageal perforation was about 10% in the worldwide, and the outcomes of esophageal perforation treatment are getting better in the last 10 years.Ethics Registration InformationLW2020011.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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