• Huanhuan Cheng, Kenneth J Ciuffreda, Huilu Jiang, Kun Zhou, Sigeng Lin, Jingwei Zheng, Xinping Yu, Balamurali Vasudevan, and Yuanbo Liang.
• Department of Ophthalmology, the First People's Hospital of Wuhu City, Wuhu.
• Medicine (Baltimore). 2021 Apr 23; 100 (16): e25618.

AbstractTo investigate the relationship between visual resolution and cone parameters in eyes with different levels of best corrected visual acuity (BCVA).Seventeen eyes of 10 volunteers with BCVA of 20/12.5 or better (group 1) and 16 eyes of 10 volunteers with BCVA of 20/16 (group 2) were investigated in the study. Images of the cone photoreceptors at 1.5° from the fovea were obtained using an adaptive optics (AO) retinal camera. The BCVA was obtained following a subjective refraction using a standardized logMAR visual acuity chart.The mean cone density (29,570.96 ± 2489.94 cells/mm2) at 1.5° from the fovea in group 1 (BCVA ≥ 20/12.5, n = 17) was significantly greater (P < .001) than that (22,963.59 ± 2987.92 cells/mm2) in group 2 (BCVA = 20/16, n = 16). The cone spacing at 1.5° from the fovea in group 1 was 6.45 ± 0.28 μm (mean ± SD), which was significantly smaller (P < .001) than 7.36 ± 0.50 μm (mean ± SD) in group 2. In the stepwise regression analysis, greater angular cone density (odds ratio [OR], 4.48; P = .005) and smaller angular cone spacing (OR, 0.60; P = .007) at 1.5° from the fovea were significantly associated with the better BCVA.The greater cone density and smaller cone spacing at the parafovea were found in eyes with BCVA of 20/12.5 or better, as compared to that in eyes with BCVA of 20/16. Knowledge of cone distribution for different BCVA levels may be beneficial for different clinical conditions.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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