• Ahmed Hasanin, Tarek Zanata, Safinaz Osman, Yasser Abdelwahab, Rania Samer, Mohamed Mahmoud, Mona Elsherbiny, Khaled Elshafaei, Fatma Morsy, and Amina Omran.
• Department of Anesthesia, Cairo University, Cairo, Egypt.
• Open Access Maced J Med Sci. 2019 Aug 15; 7 (15): 2474-2479.

BackgroundGoal-directed fluid therapy (GDFT) improved patient outcomes in various surgical procedures; however, its role during mass brain resection was not well investigated.AimIn this study, we evaluated a simple protocol based on intermittent evaluation of pulse pressure variation for guiding fluid therapy during brain tumour resection.MethodsSixty-one adult patients scheduled for supratentorial brain mass excision were randomized into either GDFT group (received intraoperative fluids guided by pulse pressure variation) and control group (received standard care). Both groups were compared according to the following: brain relaxation scale (BRS), mean arterial pressure, heart rate, urine output, intraoperative fluid intake, postoperative serum lactate, and length of hospital stay.ResultsDemographic data, cardiovascular data (mean arterial pressure and heart rate), and BRS were comparable between both groups. GDFT group received more intraoperative fluids {3155 (452) mL vs 2790 (443) mL, P = 0.002}, had higher urine output {2019 (449) mL vs 1410 (382) mL, P < 0.001}, and had lower serum lactate {0.9 (1) mmol versus 2.5 (1.1) mmol, P = 0.03} compared to control group.ConclusionIn conclusion, PPV-guided fluid therapy during supratentorial mass excision, increased intraoperative fluids, and improved peripheral perfusion without increasing brain swelling.Copyright: © 2019 Ahmed Hasanin, Tarek Zanata, Safinaz Osman, Yasser Abdelwahab, Rania Samer, Mohamed Mahmoud, Mona Elsherbiny, Khaled Elshafaei, Fatma Morsy, Amina Omran.

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