• J Plast Reconstr Aesthet Surg · Jun 2019

    Multicenter Study

    Tenosynovial giant cell tumours of the hand: A multicentre case-control study.

    • L S Linney, F Al-Hassani, J Pikturnaite, B Mathew, D Thornton, R G Wade, and R M Pinder.
    • Department of Plastic and Hand Surgery, Castle Hill Hospital Cottingham, HU16 5JQ, UK.
    • J Plast Reconstr Aesthet Surg. 2019 Jun 1; 72 (6): 918-923.

    AbstractMany factors have been proposed to contribute to the risk of recurrent tenosynovial giant cell tumours (TSGCT); however, we remain unable to predict those at risk, which formed the rationale for this multicentre retrospective case-control study of 28 patients with recurrence. We included cases of recurrence in a 1:1 ratio matched for age and sex with controls over 10 years. Using Cox regression, we present hazard ratios (HRs) for recurrence with 95% confidence intervals (CIs). Out of 285 cases, 28 individuals developed recurrence after a median of 2.4 years. Recurrent TSGCT had a higher mitotic count/mm2 in the primary tumour (median increase of 3 [IQR 1, 7]). Mitotic count in the primary tumour was associated with the risk of recurrence (adjusted HR 1.1 [95% CI 1.1, 1.2]) meaning that for every additional mitosis, the risk of recurrence increased by 10% per annum. We recommend a prospective cohort study to validate our findings.Copyright © 2019 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.

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