• M Knobel.
• Thyroid Unit, Division of Endocrinology and Metabolism, Hospital das Clínicas, School of Medicine, Universidade de São Paulo, Av. Dr. Eneas de Carvalho Aguiar, 155, 8th floor, bl 3, PAMb, São Paulo, 05403-900, Brazil. knob.ops@terra.com.br.
• J. Endocrinol. Invest. 2021 Apr 1; 44 (4): 679-691.

AbstractGoiters tend to grow slowly and steadily over many years, occasionally reaching the mediastinum and extending through the thoracic inlet into the visceral compartment. In most cases, retrosternal goiters originate from the cervical portion of the thyroid. The incidence of retrosternal goiters varies considerably, ranging from 0.2 to 45% of all thyroidectomies, depending on the criteria used to define this type of goiter. Symptoms are generally related to the compressive nature of the mass on the adjacent structures, and most patients report some form of respiratory manifestation associated with the goiter. A diagnostic assessment usually includes an evaluation of thyroid function, chest radiography, and computed tomography. Fine-needle aspiration biopsy should be avoided in substernal areas of the goiter due to limited visibility and location of vital structures in this region. Treatment of retrosternal goiters is surgical, as medical therapy is generally unsuccessful in these cases.

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