• Am. J. Med. Sci. · Jul 2021

    Review Case Reports

    Concomitant Acute Tubular Necrosis and Acute Interstitial Nephritis Induced by Tipifarnib in a Patient with Squamous Cell Carcinoma of the Lung.

    • Paula Martinez de la Cruz, Amir Shabaka, Xabier Mielgo-Rubio, Carmen Guerrero-Marquez, Sara Gimenez-Moyano, and Gema Fernandez-Juarez.
    • Nephrology Department, Hospital Universitario Fundación Alcorcón, Madrid, Spain.
    • Am. J. Med. Sci. 2021 Jul 1; 362 (1): 99-102.

    AbstractTipifarnib is a novel targeted treatment for hematologic malignancies that is being recently studied for the treatment of advanced solid organ tumors with HRAS mutations. There have been scarce reports on kidney adverse events in initial phase I and II trials. We present a case of acute kidney injury in a patient that had started treatment with tipifarnib for advanced squamous cell carcinoma of the lung. Kidney biopsy revealed acute tubular necrosis together with acute interstitial nephritis. Tipifarnib was discontinued and the patient was started with high-dose corticosteroids with an early taper completing a five-week steroid course, with full recovery of kidney function.Copyright © 2021 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved.

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