• Ugo Indraccolo, Roberto Nardulli, and Salvatore R Indraccolo.
• Obstetrics and Gynecology Unit, Department of Reproduction and Growth, Azienda Ospedaliero-Universitaria Arcispedale Sant'Anna of Cona, Ferrara, Italy.
• Neurourol. Urodyn. 2020 Mar 1; 39 (3): 890-897.

BackgroundThere is a gap between pudendal neuralgia (PN) due to pudendal entrapment syndrome and PN without pudendal entrapment syndrome. The latter could have atypical symptoms.AimDefining a rate of atypical PN from a clinical series of female patients with chronic pelvic-perineal pain.MethodsThe atypical PN was defined as a pain not meeting clinical criteria for pudendal entrapment syndrome. The effect size was the rate of atypical PN. Such a rate was expected to be found among patients screened for enrollment in clinical series on pudendal neuropathic pain. A systematic search was performed looking for clinical series on PN. Studies must report information on female patients, pelvic-perineal pain, at least a clinical criterion for diagnosing the pudendal neurogenic origin of pain, the proportion of patients with pain not meeting the clinical criterion/a for diagnosing the pudendal entrapment pain.ResultsFrom 2637 references, nine studies were included for qualitative analysis. Three of them were not suitable for data synthesis: one assessed the rate of PN after hip arthroscopy; second enrolled miscellaneous patients, a third investigated patients with gynecological diseases. Six studies involved patients with suspicion of pudendal entrapment symptoms (205 patients observed), allowing data synthesis. One of these series was judged as being of good quality. The overall rate of atypical PN is 0.013 (95% confidence interval, 0.008-0.021), I2 0%. Further analysis suggests the risk of bias for all studies.ConclusionsAtypical PN in females is low when clinical criteria for pudendal entrapment syndrome are applied.© 2020 Wiley Periodicals, Inc.

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