• Neurocritical care · Jan 2008

    Case Reports

    Baclofen and gamma-hydroxybutyrate withdrawal.

    • Jennifer L LeTourneau, Daniel S Hagg, and Stephen M Smith.
    • Division of Pulmonary & Critical Care Medicine and Center for Intensive Care Research, Department of Medicine, Oregon Health & Science University, Biomedical Research Building (UHN-67), 3181 SW Sam Jackson Park Road, Portland, OR 97239-3098, USA.
    • Neurocrit Care. 2008 Jan 1; 8 (3): 430-3.

    IntroductionBenzodiazepine treatment of life-threatening gamma-hydroxybutyrate (GHB) withdrawal is frequently unsatisfactory. Animal studies suggest strongly that treatment with GABA(B) agonists, such as baclofen, will be a more effective strategy.MethodsA case report from the medical intensive care unit (ICU) of the university tertiary care hospital.ResultsA 61-year-old woman was admitted to the medical ICU for severe withdrawal symptoms from chronic GHB use. This manifested as delirium, tremor, and seizures despite only small decreases in GHB dose and treatment with benzodiazepines. The addition of baclofen allowed the rapid sequential decreases in the GHB dose without seizure or delirium and resulted in long-term improvement of her tremor.ConclusionsBaclofen, a GABA(B) agonist, may be a useful agent in the treatment of severe GHB withdrawal.

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