• Xinqi Ge, Shichen Jiang, Ziheng Wang, Nan Hu, Rui Jiang, Zishu Cai, Bin Wu, Yu Zhang, and Peipei Gong.
• Medical School of Nantong University, Nantong, China; Department of Clinical Biobank, Nantong University Affiliated Hospital, Nantong, China.
• World Neurosurg. 2021 Jul 1; 151: e37-e46.

BackgroundGliomas, particularly high-grade gliomas, are the most common primary brain tumors. From the Chinese Glioma Genome Atlas (CGGA) database, the relationships between the altered molecular pathways and gliomas could be easily observed. A close connection in the occurrence of the pathogenesis exists between the microenvironment, the glioma, and the associated genes.MethodsValidation of the role of ZNF311 oncogene was confirmed by data from the CGGA dataset on glioblastoma and low-grade glioma. Furthermore, we used CIBERSORT to analyze the correlation between ZNF311 and cancer immune infiltrates.ResultsAccording to our analysis, ZNF311 was expressed higher in patients with grade-depended glioma with poor prognosis. In addition, we obtained valuable prognostic results between isocitrate dehydrogenase 1 (IDH1) and ZNF311 through the analysis of integrated correlations. Similarly, we simultaneously revealed the prognostic results between 1p/19q and ZNF311. In addition, we found that ZNF311 is correlated with a large number of tumor-infiltrating immune cells.ConclusionsBased on the study findings, we conclude that ZNF311 is potentially a novel biomarker for assessing prognosis and immune infiltration in glioblastoma and diffuse glioma cases.Copyright © 2021 Elsevier Inc. All rights reserved.

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