• Clinics · Jan 2021

    Systemic Inflammation and Oxidative Stress in Adults with Bronchiectasis: Association with Clinical and Functional Features.

    • Anderson Alves de Camargo, Rejane Agnelo Silva de Castro, Rodolfo P Vieira, Manoel Carneiro Oliveira-Júnior, Amanda Aparecida de Araujo, Kátia De Angelis, Samia Zahi Rached, Rodrigo Abensur Athanazio, Rafael Stelmach, and CorsoSimone DalSD0000-0001-9190-6796Programa de Pos-Graduacao em Ciencias da Reabilitacao, Universidade Nove de Julho (UNINOVE), Sao Paulo, SP, BR..
    • Programa de Pos-Graduacao em Ciencias da Reabilitacao, Universidade Nove de Julho (UNINOVE), Sao Paulo, SP, BR.
    • Clinics (Sao Paulo). 2021 Jan 1; 76: e2474.

    ObjectivesTo compare the inflammatory and oxidative stress (OS) states of adults with bronchiectasis with those of healthy controls and correlate inflammatory and OS levels with lung function and physical capacity.MethodsThis study used a cross-sectional design. Seventy-four adults with bronchiectasis (age: 49±15 years, forced expiratory volume in 1 second [FEV1]: 52.5±25.6%) and 42 healthy controls (age: 44±17 years, FEV1: 95.9±14.0%) performed cardiopulmonary exercise tests and incremental shuttle walking tests. Their physical activity in daily life, inflammatory cytokine, and antioxidant levels in plasma were measured.ResultsCompared to that of the controls, the levels of interleukin (IL)-6 (p<0.001), IL-10 (p<0.001), carbonylated proteins (p=0.001), and superoxide anions (p=0.046) were significantly increased in adults with bronchiectasis. Catalase activity was also reduced in this group (p<0.001). The inflammatory markers IL-1β, IL-6, and tumor necrosis factor-α correlated negatively with aerobic capacity (r=-0.408, r=-0.308, and r=-0.207, respectively). We observed similar correlations with OS markers (thiobarbituric acid and carbonyls; r=-0.290 and r=0.379, respectively), and these markers also significantly correlated with the aerobic capacity.ConclusionsAdults with bronchiectasis presented an increased systemic inflammatory response that correlated negatively with physical capacity.

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