• Teruo Kimura, Shigeki Yamada, Toshihide Sugimura, Toshitaka Seki, Makoto Miyano, Shin Fukuda, Satoru Takeuchi, Shiro Miyata, Adam Tucker, Tsutomu Fujita, Akira Hashizume, Naoto Izumi, Kazutsune Kawasaki, Atsushi Nakagaki, and Kazuhiro Sako.
• Department of Neurosurgery, Dohtoh Neurosurgery Hospital, Hokkaidō, Japan; Department of Neurosurgery, Kitami Red Cross Hospital, Hokkaidō, Japan. Electronic address: tekimura-nsu@umin.ac.jp.
• World Neurosurg. 2021 Jul 1; 151: e399-e406.

BackgroundSurgical treatment of idiopathic normal pressure hydrocephalus (iNPH) by ventriculoperitoneal (VP) or lumboperitoneal (LP) shunting can achieve long-term recovery of activities of daily living; however, in a subset of patients, maintenance of independence lasted for <6 months. This study examined positive preoperative predictive factors of short-term outcome for shunted iNPH patients.MethodsOver a 9-year period, consecutive patients from multiple centers diagnosed with probable iNPH underwent either VP or LP shunt surgery. Preoperative variables of age, symptom duration, iNPH severity, tap test response, and magnetic resonance imaging findings of disproportionately enlarged subarachnoid space hydrocephalus (DESH) or incomplete DESH were retrospectively evaluated in relation to 1-year postoperative outcome.ResultsOutcome for 154 shunt patients (12 VP, 142 LP) as measured by postoperative disability modified Rankin Scale (mRS) and iNPH-gait disturbance (GD) was the same regardless of age. Symptom duration was inversely correlated with both iNPH severity (P < 0.0001) and postoperative improvement at 1 year (P = 0.0015). Severity also correlated inversely with postoperative improvement at 1 year (P < 0.0001). Age was not significantly correlated with the degree of postoperative improvement (mRS: P = 0.487; iNPH grading scale [GD]: P = 0.725). Outcome at 1 year (mRS, gait domain, and activities of daily living significantly improved in patients with a good response to the tap test (P < 0.0001) Preoperative DESH correlated with improvement in mRS and GD (P < 0.0001).ConclusionsMild preoperative iNPH severity, shorter preoperative symptom duration, good tap test response, and complete DESH were associated with good short-term postoperative outcome at 1 year. These positive factors may be useful for prediction of short-term surgical outcome in iNPH patients.Copyright © 2021. Published by Elsevier Inc.

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